Full name: FKBP prolyl isomerase 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FKBP-25; FKBP-3; FKBP25; PPIase

Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

Expression: Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues

Gene size: 18883bp

Exon count: 8