Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 22596)
Source: NCBI Gene (ID 22596)
Symbol: Xrcc5
Full name: X-ray repair complementing defective repair in Chinese hamster cells 5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: CTC85; CTCBF; Ku80; Ku86
Summary: Predicted to enable several functions, including nucleic acid binding activity; protein C-terminus binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity and double-stranded telomeric DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic stem cell differentiation; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 10.7), placenta adult (RPKM 9.8) and 24 other tissues
Orthologs: human
Gene size: 87537bp
Exon count: 22