Full name: eukaryotic translation initiation factor 4H

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: D5Ertd355e; E430026L18Rik; Ef4h; Wbscr1; Wscr1; eIF-4H

Summary: This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Expression: Ubiquitous expression in CNS E11.5 (RPKM 110.9), large intestine adult (RPKM 109.6) and 28 other tissues

Gene size: 19538bp

Exon count: 7