Full name: vinculin

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 9430097D22

Summary: Predicted to enable alpha-catenin binding activity; dystroglycan binding activity; and enzyme binding activity. Acts upstream of or within cell adhesion; plasma membrane bounded cell projection organization; and regulation of cell migration. Located in several cellular components, including costamere; fascia adherens; and focal adhesion. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in bladder adult (RPKM 91.6), lung adult (RPKM 52.4) and 26 other tissues

Gene size: 104309bp

Exon count: 22