Top2a topoisomerase (DNA) II alpha [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 21973)
Source: NCBI Gene (ID 21973)
Symbol: Top2a
Full name: topoisomerase (DNA) II alpha
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: Top-2
Summary: Enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including DNA conformation change; embryonic cleavage; and hematopoietic progenitor cell differentiation. Located in chromosome, centromeric region; condensed chromosome; and nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 10 other tissues
Orthologs: human
Gene size: 31265bp
Exon count: 36