Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 21934)
Source: NCBI Gene (ID 21934)
Symbol: Tnfrsf11a
Full name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK
Summary: Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mammary gland alveolus development; and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 20.9), duodenum adult (RPKM 8.1) and 10 other tissues
Orthologs: human
Gene size: 68725bp
Exon count: 10