Full name: tumor necrosis factor

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DIF; TNF-a; TNF-alpha; TNFSF2; TNFalpha; Tnfa; Tnfsf1a; Tnlg1f

Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Expression: Broad expression in spleen adult (RPKM 4.1), thymus adult (RPKM 3.0) and 16 other tissues

Gene size: 2641bp

Exon count: 4