Full name: tissue inhibitor of metalloproteinase 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: D11Bwg1104e; Timp-2

Summary: Enables enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in bladder adult (RPKM 237.6), lung adult (RPKM 168.3) and 23 other tissues

Gene size: 54351bp

Exon count: 5