Full name: thyroid hormone receptor beta

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Nr1a2; T3R[b]; T3Rbeta; Thrb1; Thrb2; c-erbAbeta

Summary: Enables chromatin DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including female mating behavior; regulation of transcription by RNA polymerase II; and retinal cone cell apoptotic process. Located in nucleus. Is expressed in several structures, including brown fat; endocrine gland; liver; sensory organ; and vestibulo-cochlear ganglion. Used to study attention deficit hyperactivity disorder; thyroid gland follicular carcinoma; and thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in cortex adult (RPKM 2.1), adrenal adult (RPKM 2.1) and 24 other tissues

Gene size: 380940bp

Exon count: 18