Full name: CDK5 regulatory subunit associated protein 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 2900018K03Rik; an; mKIAA1633

Summary: Predicted to enable several functions, including 14-3-3 protein binding activity; calmodulin binding activity; and tubulin binding activity. Involved in several processes, including establishment of mitotic spindle orientation; negative regulation of centriole replication; and nervous system development. Located in centrosome and mitotic spindle pole. Is expressed in central nervous system and retina. Used to study microcephaly. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to several human genes including CDK5RAP2 (CDK5 regulatory subunit associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in testis adult (RPKM 11.0), CNS E11.5 (RPKM 5.7) and 23 other tissues

Gene size: 193581bp

Exon count: 37