Full name: lysine (K)-specific methyltransferase 2A

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 6430520K01; ALL-1; All1; Cxxc7; HRX; HTRX1; Mll; Mll1; mKIAA4050

Summary: Enables DNA binding activity; chromatin binding activity; and histone methyltransferase activity (H3-K4 specific). Involved in several processes, including definitive hemopoiesis; regulation of gene expression; and regulation of histone modification. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in thymus adult (RPKM 13.7), spleen adult (RPKM 10.1) and 28 other tissues

Gene size: 78841bp

Exon count: 38