Full name: T cell acute lymphocytic leukemia 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Hpt; SCL/tal-1; Scl; bHLHa17; tal-1

Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in liver E14.5 (RPKM 43.3), liver E14 (RPKM 39.2) and 8 other tissues

Gene size: 15330bp

Exon count: 9