Full name: MDS1 and EVI1 complex locus

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1; PRDM3; RUSAT2

Summary: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Expression: Broad expression in stomach (RPKM 15.9), kidney (RPKM 12.6) and 18 other tissues

Gene size: 580206bp

Exon count: 24