Full name: ETS proto-oncogene 1, transcription factor

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ETS-1; EWSR2; c-ets-1; p54

Summary: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Expression: Broad expression in lymph node (RPKM 31.2), spleen (RPKM 21.4) and 22 other tissues

Gene size: 128794bp

Exon count: 13