Stxbp1 syntaxin binding protein 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 20910)
Source: NCBI Gene (ID 20910)
Symbol: Stxbp1
Full name: syntaxin binding protein 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: MMS10-G; Ms10g; Munc-18a; Munc18-1; N-sec1; Rb-sec1; Sxtbp1; Unc18-1; Unc18h; nsec1
Summary: Enables syntaxin-1 binding activity. Involved in presynaptic dense core vesicle exocytosis and synaptic vesicle priming. Acts upstream of or within several processes, including axon target recognition; chemical synaptic transmission; and negative regulation of synaptic transmission. Located in several cellular components, including glutamatergic synapse; phagocytic vesicle; and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4. Orthologous to human STXBP1 (syntaxin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 216.7), cortex adult (RPKM 165.3) and 6 other tissues
Orthologs: human
Gene size: 59631bp
Exon count: 20