Full name: erb-b2 receptor tyrosine kinase 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ALS19; HER4; p180erbB4

Summary: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Expression: Biased expression in kidney (RPKM 3.0), brain (RPKM 2.7) and 8 other tissues

Gene size: 1163086bp

Exon count: 31