Full name: adenylate kinase 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AK 4; AK3; AK3L1; AK3L2

Summary: This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Expression: Biased expression in kidney (RPKM 79.4), liver (RPKM 24.7) and 11 other tissues

Gene size: 84594bp

Exon count: 9