Full name: sorbin and SH3 domain containing 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 2310065E01Rik; 9530001P15Rik; CAP; SH3P12; Sh3d5; mKIAA1296

Summary: Enables enzyme binding activity; insulin receptor binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including focal adhesion assembly; positive regulation of biosynthetic process; and positive regulation of glucose import. Acts upstream of or within acetylcholine receptor signaling pathway and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in several cellular components, including adherens junction; nuclear matrix; and stress fiber. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in bladder adult (RPKM 34.6), subcutaneous fat pad adult (RPKM 30.5) and 24 other tissues

Gene size: 221916bp

Exon count: 37