Scn8a sodium channel, voltage-gated, type VIII, alpha [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 20273)
Source: NCBI Gene (ID 20273)
Symbol: Scn8a
Full name: sodium channel, voltage-gated, type VIII, alpha
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: C630029C19Rik; NaCh6; Nav1.6; dmu; med; mnd-2; mnd2; nmf2; nmf335; nmf58; nur14; seal
Summary: Predicted to enable sodium ion binding activity and voltage-gated sodium channel activity. Acts upstream of or within several processes, including adult walking behavior; muscle organ development; and sensory perception of sound. Located in several cellular components, including Z disc; neuronal cell body; and node of Ranvier. Part of sodium channel complex. Is expressed in several structures, including heart; metanephros; nervous system; and nucleus pulposus. Used to study early infantile epileptic encephalopathy and epilepsy. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 21.8), cerebellum adult (RPKM 21.1) and 5 other tissues
Orthologs: human
Gene size: 177220bp
Exon count: 31