Full name: polymerase (RNA) I polypeptide C

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 40kDa; Polr1e; RPA40; Rpo1-1

Summary: Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription, DNA-templated. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; genitourinary system; midbrain; respiratory system; and telencephalon. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in CNS E11.5 (RPKM 45.3), limb E14.5 (RPKM 32.8) and 28 other tissues

Gene size: 4126bp

Exon count: 9