Full name: integrin beta 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: C230078O20; CD104

Summary: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Biased expression in colon adult (RPKM 42.1), small intestine adult (RPKM 34.8) and 13 other tissues

Gene size: 33688bp

Exon count: 42