Full name: prostaglandin E receptor 4 (subtype EP4)

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: EP4; Ptgerep4

Summary: Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; regulation of cytokine production; and regulation of stress fiber assembly. Acts upstream of or within several processes, including cellular response to mechanical stimulus; regulation of ossification; and response to lipopolysaccharide. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; early conceptus; heart valve; retina; and secondary oocyte. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in small intestine adult (RPKM 27.1), colon adult (RPKM 22.4) and 14 other tissues

Gene size: 10789bp

Exon count: 3