Full name: patched 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: A230106A15Rik; Ptc; Ptc1; Ptch; mes; wig

Summary: Enables cyclin binding activity; heparin binding activity; and patched binding activity. Involved in several processes, including chordate embryonic development; negative regulation of smoothened signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and limb morphogenesis. Located in cilium; midbody; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and urinary system. Used to study basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in ovary adult (RPKM 23.7), limb E14.5 (RPKM 16.2) and 28 other tissues

Gene size: 65133bp

Exon count: 25