Full name: suppression of tumorigenicity 14 (colon carcinoma)

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Epithin; MT-SP1; Prss14; Tmprss14; mCAP3; matriptase

Summary: Enables serine-type endopeptidase activity. Acts upstream of or within epithelial cell morphogenesis involved in placental branching and neural tube closure. Located in extracellular region. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; pituitary gland; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in colon adult (RPKM 92.3), small intestine adult (RPKM 64.9) and 12 other tissues

Gene size: 43253bp

Exon count: 21