Pola1 polymerase (DNA directed), alpha 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 18968)
Source: NCBI Gene (ID 18968)
Symbol: Pola1
Full name: polymerase (DNA directed), alpha 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: Pola
Summary: Enables DNA-directed DNA polymerase activity. Involved in DNA replication, synthesis of RNA primer. Acts upstream of or within DNA replication. Located in nucleus. Part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 4.9), liver E14 (RPKM 4.7) and 15 other tissues
Orthologs: human
Gene size: 327622bp
Exon count: 39