Full name: plasminogen activator, urokinase

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: u-PA; uPA

Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Predicted to be located in cell surface and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; fatty liver disease; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in kidney adult (RPKM 100.9), bladder adult (RPKM 27.0) and 5 other tissues

Gene size: 6727bp

Exon count: 12