Full name: phosphoinositide-3-kinase regulatory subunit 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: p85beta

Summary: Enables phosphatidylinositol 3-kinase regulatory subunit binding activity and protein heterodimerization activity. Involved in several processes, including cellular glucose homeostasis; insulin receptor signaling pathway; and positive regulation of protein import into nucleus. Acts upstream of or within positive regulation of cell adhesion; regulation of actin filament organization; and regulation of protein localization to plasma membrane. Located in focal adhesion and nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; musculature; and spleen. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in ovary adult (RPKM 65.5), duodenum adult (RPKM 57.1) and 28 other tissues

Gene size: 8550bp

Exon count: 17