Full name: paired box 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Pax-1; hbs; hunchback; un; undulated; wt

Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development; cell population proliferation; and somitogenesis. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including branchial pouch; central nervous system; embryo mesenchyme; limb; and musculoskeletal system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome. Orthologous to human PAX1 (paired box 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in thymus adult (RPKM 22.9), testis adult (RPKM 3.3) and 2 other tissues

Gene size: 13123bp

Exon count: 6