P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 18439)
Source: NCBI Gene (ID 18439)
Symbol: P2rx7
Full name: purinergic receptor P2X, ligand-gated ion channel, 7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: P2X(7); P2X7R
Summary: Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and lipopolysaccharide binding activity. Involved in negative regulation of cell volume and sensory perception of pain. Acts upstream of or within several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is integral component of plasma membrane. Is expressed in brain; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues
Orthologs: human
Gene size: 48410bp
Exon count: 16