Full name: sigma non-opioid intracellular receptor 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Oprs1; Sig1R; sigma1R

Summary: This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]

Expression: Ubiquitous expression in liver adult (RPKM 37.0), subcutaneous fat pad adult (RPKM 22.3) and 28 other tissues

Gene size: 2867bp

Exon count: 4