Full name: opioid receptor-like 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: KOR-3; KOR3; LC132; MOR-C; NOP; ORGC; ORL1; Oprl; XOR1; morc

Summary: The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Expression: Biased expression in whole brain E14.5 (RPKM 16.2), CNS E18 (RPKM 14.7) and 6 other tissues

Gene size: 6194bp

Exon count: 7