Full name: regulator of calcineurin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1

Summary: The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Expression: Broad expression in liver (RPKM 56.9), placenta (RPKM 30.5) and 22 other tissues

Gene size: 98672bp

Exon count: 9