Full name: neurotrophin 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: HDNF; NGF-2; Nt3; Ntf-3

Summary: This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]

Expression: Broad expression in bladder adult (RPKM 4.6), limb E14.5 (RPKM 4.0) and 21 other tissues

Gene size: 65360bp

Exon count: 4