Full name: dipeptidyl peptidase 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ADABP; ADCP2; CD26; DPPIV; TP103

Summary: The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]

Expression: Biased expression in small intestine (RPKM 70.7), placenta (RPKM 57.1) and 13 other tissues

Gene size: 81971bp

Exon count: 28