Full name: neurofibromin 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: merlin

Summary: Predicted to enable beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in lens fiber cell differentiation. Acts upstream of or within several processes, including negative regulation of MAPK cascade; negative regulation of protein kinase activity; and nervous system development. Located in several cellular components, including adherens junction; cleavage furrow; and ruffle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study familial meningioma; neurofibromatosis; otitis media; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in adrenal adult (RPKM 31.2), testis adult (RPKM 20.8) and 28 other tissues

Gene size: 83700bp

Exon count: 21