Myd88 myeloid differentiation primary response gene 88 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 17874)
Source: NCBI Gene (ID 17874)
Symbol: Myd88
Full name: myeloid differentiation primary response gene 88
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Summary: Enables Toll-like receptor binding activity and interleukin-1 receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in cerebral cortex; embryo; and telencephalon. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 14.9), spleen adult (RPKM 14.1) and 28 other tissues
Orthologs: human
Gene size: 4085bp
Exon count: 6