Full name: Meis homeobox 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: A430109D20Rik; Mrg1; Stra10

Summary: This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Expression: Broad expression in frontal lobe adult (RPKM 31.3), CNS E14 (RPKM 21.9) and 17 other tissues

Gene size: 206181bp

Exon count: 19