Full name: myeloproliferative leukemia virus oncogene

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CD110; TPO-R; c-mpl; hlb219

Summary: Predicted to enable thrombopoietin receptor activity. Involved in thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of stem cell division. Predicted to be located in several cellular components, including Golgi apparatus; neuronal cell body; and nuclear membrane. Is expressed in several structures, including brain; hemolymphoid system; mesenchyme derived from splanchnopleure; reproductive system; and spinal cord. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in spleen adult (RPKM 4.4), liver E14.5 (RPKM 3.8) and 7 other tissues

Gene size: 15163bp

Exon count: 12