Full name: matrix metallopeptidase 14 (membrane-inserted)

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: MMP-X1; MT-MMP-1; MT1-MMP; sabe

Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]

Expression: Broad expression in ovary adult (RPKM 116.4), limb E14.5 (RPKM 100.7) and 24 other tissues

Gene size: 10859bp

Exon count: 10