Full name: transformed mouse 3T3 cell double minute 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 4933417N07Rik; Mdmx

Summary: This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Expression: Ubiquitous expression in limb E14.5 (RPKM 31.1), CNS E14 (RPKM 26.8) and 26 other tissues

Gene size: 44483bp

Exon count: 14