Full name: lymphotoxin A

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: LT; LT-[a]; LT-alpha; LT[a]; LTalpha; Ltx; TNF-beta; TNFSF1; Tnfb; Tnfsf1b; Tnlg1e; hlb382

Summary: Predicted to enable tumor necrosis factor receptor binding activity. Acts upstream of or within several processes, including lymph node development; positive regulation of immune response; and positive regulation of interferon-gamma production. Predicted to be located in extracellular space. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in spleen adult (RPKM 15.0), mammary gland adult (RPKM 7.3) and 2 other tissues

Gene size: 2428bp

Exon count: 4