Full name: luteinizing hormone/choriogonadotropin receptor

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Gpcr19-rs1; LH-R; LH/CG-R; LSH-R; Lhr

Summary: Enables choriogonadotropin hormone binding activity and choriogonadotropin hormone receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; and positive regulation of inositol trisphosphate biosynthetic process. Acts upstream of or within several processes, including development of secondary male sexual characteristics; regulation of steroid hormone biosynthetic process; and reproductive structure development. Is integral component of plasma membrane. Is expressed in early conceptus; medulla oblongata; medulla oblongata basal plate ventricular layer; oocyte; and testis. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Restricted expression toward ovary adult (RPKM 46.2)

Gene size: 75676bp

Exon count: 14