Full name: lymphocyte-activation gene 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CD223; LAG-3; Ly66

Summary: Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in thymus adult (RPKM 7.2), spleen adult (RPKM 4.9) and 19 other tissues

Gene size: 7347bp

Exon count: 8