Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 16531)
Source: NCBI Gene (ID 16531)
Symbol: Kcnma1
Full name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 5730414M22Rik; BKCA alpha; BKCa; KCa1.1; MaxiK; Slo; Slo1; k(VCA)alpha; mSlo; mSlo1; slo-alpha
Summary: Enables identical protein binding activity; large conductance calcium-activated potassium channel activity; and voltage-gated potassium channel activity. Acts upstream of or within several processes, including adult walking behavior; eye blink reflex; and locomotor rhythm. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and postsynaptic membrane. Is integral component of membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 10.4), frontal lobe adult (RPKM 9.3) and 12 other tissues
Orthologs: human
Gene size: 712818bp
Exon count: 36