Full name: junction plakoglobin

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Ctnng; D930025P04Rik; PG

Summary: Enables alpha-catenin binding activity. Acts upstream of or within cell-cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including Z disc; adherens junction; and intermediate filament. Part of catenin complex. Is expressed in several structures, including alimentary system; musculature; nervous system; reproductive system; and sensory organ. Used to study arrhythmogenic right ventricular dysplasia 12 and epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in lung adult (RPKM 160.5), stomach adult (RPKM 151.6) and 23 other tissues

Gene size: 28958bp

Exon count: 15