Itpr2 inositol 1,4,5-triphosphate receptor 2 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 16439)
Source: NCBI Gene (ID 16439)
Symbol: Itpr2
Full name: inositol 1,4,5-triphosphate receptor 2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: InsP3R-2; InsP3R-5; Ip3r2; Itpr5; insP3R2
Summary: Enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in cellular response to cAMP. Acts upstream of or within calcium ion transport and cellular response to ethanol. Located in cell cortex and sarcoplasmic reticulum. Is expressed in several structures, including heart; liver; medulla oblongata; skeletal muscle; and spleen. Used to study isolated anhidrosis with normal sweat glands. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 9.6), kidney adult (RPKM 6.8) and 23 other tissues
Orthologs: human
Gene size: 393961bp
Exon count: 58