Full name: inositol polyphosphate-5-phosphatase D

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: SHIP; SHIP-1; SHIP1; SIP-145; p150Ship; s-SHIP

Summary: Enables phosphatase activity and protein domain specific binding activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; negative regulation of bone resorption; and regulation of hemopoiesis. Predicted to be located in actin filament; cortical cytoskeleton; and cytosol. Predicted to colocalize with plasma membrane. Is expressed in several structures, including integumental system; nervous system; respiratory system; skeleton; and spleen. Used to study Paget's disease of bone and systemic lupus erythematosus. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in spleen adult (RPKM 30.1), genital fat pad adult (RPKM 21.2) and 20 other tissues

Gene size: 100199bp

Exon count: 29