Full name: inositol polyphosphate-5-phosphatase B

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 5PTase; INPP5P

Summary: This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Expression: Ubiquitous expression in lung adult (RPKM 14.1), thymus adult (RPKM 13.5) and 28 other tissues

Gene size: 59685bp

Exon count: 25