Full name: D-amino acid oxidase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DAAO; DAMOX; OXDA

Summary: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

Expression: Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1)

Gene size: 20952bp

Exon count: 12