Full name: isocitrate dehydrogenase 1 (NADP+), soluble

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: E030024J03Rik; Id-1; Idh-1; Idpc

Summary: Enables isocitrate dehydrogenase (NADP+) activity. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in kidney adult (RPKM 104.0), CNS E18 (RPKM 83.7) and 25 other tissues

Gene size: 27864bp

Exon count: 10